Ultrastructural localization of the likely mechanoelectrical transduction channel protein, transmembrane-like channel 1 (TMC1) during development of cochlear hair cells
نویسندگان
چکیده
منابع مشابه
The effects of Tmc1 Beethoven mutation on mechanotransducer channel function in cochlear hair cells.
Sound stimuli are converted into electrical signals via gating of mechano-electrical transducer (MT) channels in the hair cell stereociliary bundle. The molecular composition of the MT channel is still not fully established, although transmembrane channel-like protein isoform 1 (TMC1) may be one component. We found that in outer hair cells of Beethoven mice containing a M412K point mutation in ...
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The mechanoelectrical-transduction channel of the hair cell is permeable to both monovalent and divalent cations. Because Ca2+ entering through the transduction channel serves as a feedback signal in the adaptation process that sets the channel's open probability, an understanding of adaptation requires estimation of the magnitude of Ca2+ influx. To determine the Ca2+ current through the transd...
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The tip link protein protocadherin 15 (PCDH15) is a central component of the mechanotransduction complex in auditory and vestibular hair cells. PCDH15 is hypothesized to relay external forces to the mechanically gated channel located near its cytoplasmic C terminus. How PCDH15 is coupled to the transduction machinery is not clear. Using a membrane-based two-hybrid screen to identify proteins th...
متن کاملStochastic resonance in the mechanoelectrical transduction of hair cells.
In transducing mechanical stimuli into electrical signals, at least some hair cells in vertebrate auditory and vestibular systems respond optimally to weak periodic signals at natural, nonzero noise intensities. We understand this stochastic resonance by constructing a faithful mechanical model reflecting the hair cell geometry and described by a nonlinear stochastic differential equation. This...
متن کاملDevelopmental changes in the cochlear hair cell mechanotransducer channel and their regulation by transmembrane channel–like proteins
Vibration of the stereociliary bundles activates calcium-permeable mechanotransducer (MT) channels to initiate sound detection in cochlear hair cells. Different regions of the cochlea respond preferentially to different acoustic frequencies, with variation in the unitary conductance of the MT channels contributing to this tonotopic organization. Although the molecular identity of the MT channel...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2019
ISSN: 2045-2322
DOI: 10.1038/s41598-018-37563-x